Christian art of the 14th century, the pre-Renaissance era, was dominated by Giotto - see the Scrovegni (Arena) Chapel Frescoes (c.1303-10) - and Duccio de Buoninsegna (1255-1318) - see the celebrated polyptych for Siena Cathedral, known as the Maesta Altarpiece (1308-11). After this came the Early Renaissance in Florence, exemplified by the city's duomo - for more, see: Florence Cathedral, Brunelleschi and the Renaissance (1420-36) - Masaccio (Brancacci Chapel frescoes) and Donatello (statue of David). If 15th century Christian art was dominated by Florence, the centre of 16th century Christian art was Rome, where the greatest patrons were Pope Sixtus IV (1471-84), Pope Julius II (1503-13), Pope Leo X (1513-21) and Pope Paul III (1534-49). Scripture Art